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PHI Receives $1.8 Million from NIH to Detect Community-Acquired Antimicrobial Resistance Associated with Food-Animal Production

January 02, 2018

A collaborative research team, led by PHI, has been awarded a $1.8 million, four-year grant by the National Institutes of Health to apply epidemiologic methods and next-generation DNA sequencing to quantify the transmission of antimicrobial resistance (AMR) between food-animals and children living in peri-urban parishes east of Quito, Ecuador—an area where small- and large-scale food-animal production is widespread.

“The collaborative study will be one of the first to characterize community transmission of AMR associated with food-animal production and my hope is that this study will increase our understanding of important mechanistic questions of transmission,” said Jay Graham, the lead investigator of the study.

Graham and his colleagues from the Universidad San Francisco de Quito and the University of Minnesota recently discovered evidence of active transmission of AMR between domestic animals and humans. This new study will build off of the previous pilot research to identify which risk factors are driving AMR transmission. In addition to applying advance molecular microbiology, the research will include a strong qualitative component to identify the socioeconomic factors for antibiotic use in food-animal production so that use in this sector can be reduced.

The new NIH-funded project, titled, “Antimicrobial resistance transmission associated with small-scale food-animal production in peri-urban communities of Quito, Ecuador” is funded by the National Institutes of Allergy and Infectious Diseases at NIH.